PELP1—A novel estrogen receptor-interacting protein

MICoA, a Novel MTA 1 Interacting Protein Coactivator, Regulates Estrogen Receptor-alpha Transactivation Functions*

The transcriptional activity of estrogen receptor-alpha (ER) is modified by coactivators, corepressors and chromatin remodeling complexes. We have previously shown that the metastasis-associated protein-1 (MTA1), a component of histone deacetylase and nucleosome remodeling complexes, represses ER-driven transcription by recruiting histone deacetylases (HDACs) to the estrogen receptor element (E...

Novel estrogen receptor discovered.

T here are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins’ subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances ...

SMILE, a new orphan nuclear receptor SHP-interacting protein, regulates SHP-repressed estrogen receptor transactivation.

SHP (small heterodimer partner) is a well-known NR (nuclear receptor) co-regulator. In the present study, we have identified a new SHP-interacting protein, termed SMILE (SHP-interacting leucine zipper protein), which was previously designated as ZF (Zhangfei) via a yeast two-hybrid system. We have determined that the SMILE gene generates two isoforms [SMILE-L (long isoform of SMILE) and SMILE-S...

Receptor-Interacting Protein Homotypic

Identification of novel G protein-coupled receptor-interacting proteins.

Biochemical and genetic methods utilizing G protein-coupled receptor fragments have been used successfully to identify G protein-coupled receptor-interacting proteins. As noted earlier, these methods may be unable to detect interactions that require certain conformations of the native receptor protein, but have nevertheless proven quite useful in expanding our understanding of receptor regulati...